Executive Medical Director, Global Medical Lead (Pain)

• Lead the development, implementation, execution, and communication of the Integrated Medical Plans, including but not limited to medical strategy, global tactical plan, publication, congress and post-approval evidence generation plan, in collaboration with Clinical Development, HEOR, RWE, Medical Writing, and other internal stakeholders across Vertex

• Ensure alignment of medical strategy with organizational objectives by integrating individual and disease area team goals with Vertex and DST priorities, and the goals of cross-functional partners

• Expertly distills insights and actionable outcomes that inform strategy and drive the greatest impact for Medical Affairs

• Establishes and tracks medical KPIs that demonstrate impact on business and patient outcomes.

• Applies structured problem-solving and root cause analysis to identify solutions and make decisions that maximize medical and business impact

• Able to identify what is important and impactful to medical and the wider business, prioritize competing demands and communication to key stakeholders

• Accountable for development of the global DA budget, management of funds allocation, and associated tracking to ensure alignment with Medical Affairs priorities and efficient resource allocation

Scientific Excellence

• Serve as product and disease area expert and primary contact point for all global disease area related issues with the external community and internally at Vertex

• Able to lead development of peer reviewed publications, congress presentations and evidence generation to shape clinical practice

• Closely follow medical developments within disease area and disseminate new information to transform clinical trends and emerging data into new plans

• Lead the development of global scientific communications and materials including materials for global led symposia, advisory boards, and training.

• Accountable for medical review of assigned brand related content and global medical content aligned with Vertex SOPs

External Partnerships

• Represent Vertex at scientific and medical forums, including medical education forums, scientific societies, patient advocacy groups, and congresses.

• Accountable for engaging and cultivating relationships with leading global key thought leaders (TL) to gain greater understanding of the disease area, and insights into unmet patient needs

Medical Communication

• Tailors communication to stakeholder needs, building trust and understanding across diverse audiences.

• Deliver external presentations (advisory board meetings, symposia, other medical education meetings) to enhance the medical knowledge of pipeline and marketed products, as required and in accordance with relevant regulations and procedures

• Support disease area training across the company as required

• Responsible for medical interpretation of data (clinical trials, registries, published literature, etc.) for pipeline therapies and marketed medicines

Regional Medical and Cross Functional Collaboration

• Accountable for go to market model and medical partnership in commercialization with global cross-functional colleagues. In absence of regions teams, country go to market model remains the responsibility of the GML.

• Support regional Medical Affairs and Medical Excellence teams from launch through lifecycle via timely delivery of fit-for-purpose training and core materials.

• Responsible for driving alignment on medical content/messaging within the organization to ensure maximal functional and regional input.

• Medical Affairs leader on key global cross-functional product and development strategic focused teams, including DST and relevant sub teams

• Effectively represents and communicates DST priorities to the medical function and proactively communicates and represents medical needs to DST

• Chair the Global Medical Area Team (GMAT) for the disease area and accountable for deliverables

• Provide strategic Medical Affairs leadership on relevant commercial teams: Launch Team, and Global brand teams for product

• Represent Medical Affairs in label discussions

• Support Access, Patient Advocacy, Policy, and Corporate Communications teams with medical/scientific expertise and materials review.

Evidence Generation and Access

• Leads strategy, development and execution of Life Cycle Management in partnership with HEOR, including Integrated Evidence Generation plan in close collaboration with key internal stakeholders

• May act as medical monitor for studies falling under the Medical Affairs scope in collaboration with Clinical Development, Real World Evidence, Health Economics and Outcomes Research, and Clinical Operations

• Lead oversight and management of ISS programs, and in collaboration with Regional Medical leadership, conduct critical scientific and medical review of ISS protocols

• As applicable, lead Managed Access Committee for assets with a Managed Access Program (MAP); may act as a Medical Monitor for MAP

Team/People Management

• Provide strong leadership to dedicated disease area medical team, inspiring and empowering a dedicated medical team, and promoting a culture of continuous development.

• Accountable for the recruitment, development, management and coaching the global medical team

• Leverages the capabilities and expertise of the team to ensure successful execution of medical plans

• Identifies and addresses team skill gaps, considering how to accelerate internal talent or attract external to meet needs of a future-ready organization.

• Adheres to formal goal-setting, talent and performance cycles ensuring individual development plans (IDPs) are in place

• Navigates ambiguous or rapidly evolving situations, and coach the team during periods of uncertainty or change.

Compliance and Pharmacovigilance:

• Ensure compliance of medical activities according to global and regional guidelines and in accordance with Vertex Code of Conduct, rules and regulations, company policies, SOPs, GCP and ICH

• Ensure self and other medical colleagues have the required skills to identify and report AEs appropriately

• Contribute to managing external communication when significant safety issues arise, with the wellbeing of patients being the ultimate goal