Post-Doctoral Associate

The postdoctoral associate will lead a semi-independent investigation into the molecular mechanisms of protein toxins and/or secretion systems produced by Gram-positive bacteria. The successful candidate will work in collaboration with laboratory members as a part of an interdisciplinary research team focused on addressing longstanding questions in toxin biochemistry. The candidate is expected to contribute to the intellectual and scientific environment of the laboratory by sharing ideas, critically evaluating experimental results, and participating in scientific discussions. The candidate will also communicate their research findings internally and externally.

The following workload is anticipated:

90% Research:
The postdoctoral associate will contribute to a federally research project. All work will be conducted semi-independently and in line with the goals of this project. The candidate will use a variety of techniques to accomplish these goals including the following:

Molecular Biology: PCR, Gibson Assembly, Site-Directed Mutagenesis, etc.
Protein Biochemistry: Affinity Chromatography, Chemical Labelling, Enzymatic Processing, etc.
Biochemical Characterization: Fluorescence-Based Activity Assays, Immunoblotting, etc.
Biophysical Analysis: Cryo-EM, Biolayer Interferometry (BLI), Surface Plasmon Resonance (SPR), etc.
Cell-based assays: Development experiments to investigate toxin activity in mammalian cells.

General Laboratory Responsibilities (5%):
The postdoctoral associate will contribute to the effective operation and organization of the laboratory. Responsibilities will include ordering supplies, maintaining laboratory equipment, and preparing and replenishing common reagents.

Training and Mentorship (5%):
The postdoctoral associate will assist in training and mentoring undergraduate and/or graduate students in fundamental laboratory techniques, as appropriate to their research experience and the needs of the laboratory.

Required Qualifications:
Applicants must meet the following qualifications to be considered for this position:

Completed a Ph.D. in biochemistry, microbiology, chemistry, pharmacology, or related field in the last two years.
Research experience in one or more of the following areas: bacteriology, cell biology, structural biology, or biochemistry.
Proficiency in Microsoft Office applications including Word, Excel, and PowerPoint.
Strong oral and written communication skills.

Preferred Qualifications:
The following qualifications are preferred:

Research experience with one or more of the following techniques: bacterial genetics, cryogenic electron microscopy (Cryo-EM), X-ray crystallography, and/or biochemical assay development.
Familiarity with Linux-based operating systems.
Experience with data analysis and scientific imaging software, including GraphPad Prism, ImageJ, CellProfiler, CryoSPARC, and RELION.

Pharmacology

The Department of Pharmacology at the University of Minnesota is one of six basic science departments in the Medical School. The well-funded research programs of our primary faculty members focus on understanding and developing better treatments for cancer, addiction and the opioid crisis, cardiovascular disease, infectious disease, and metabolic syndrome. We also offer an undergraduate Pharmacology Minor, oversee the Molecular Pharmacology and Therapeutics Graduate Program (MPaT), teach fundamental principles of pharmacology to students in professional degree programs (MD, DDS, and MD/PhD), and provide individualized training experiences for our strong community of postdoctoral scholars. Our past trainees are now applying their skills to impactful careers in academia, medicine, industry, government, law, and regulatory oversight. We are proud of our role in preparing the next generation of scientists for rewarding careers in the health sciences and related professions, and for the various other ways we give back to our community.

Pay Range: $64,380.00; depending on education/qualifications/experience

Please visit the Benefits for Postdoctoral Candidates website for more information regarding benefit eligibility.

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training
• Medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and life insurance
• Employee wellbeing program
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail jobcentr@umn.edu.

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

At the University of Minnesota, we are proud to be recognized by Forbes as a Best Employer for Company Culture (2026), Best Employer for Women (2023, 2025, 2026), and Best Employer by State (2022-2026). In 2026, we also received Culture Excellence & Industry Awards recognition for employee appreciation and work-life flexibility.